Article
Whole-exome sequencing reveals potential mechanisms of drug resistance to FGFR3-TACC3 targeted therapy and subsequent drug selection: towards a personalized medicine.
BMC medical genomics - 21 Sept 2020
Tong Zhou, Yan Cong, Dong Yu-An, Yao Ming, Zhang Hangyu, Liu Lulu, Zheng Yi, Zhao Peng, Wang Yimin, Fang Weijia, Zhang Feifei, Jiang Weiqin
Abstract excerpt
BACKGROUND: Drug resistance is a major obstacle to effective cancer therapy. In order to detect the change in tumor genomic states under drug selection pressure, we use next-generation sequencing technology to investigate the underlying potential mechanisms of drug resistance. METHODS: In our study, we presented a bladder cancer patient who had been a bona fide responder to first-line gemcitabine plus cisplatin...
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