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Article

FOLFOXIRI Resistance Induction and Characterization in Human Colorectal Cancer Cells

30 Sept 2022

Abstract excerpt

FOLFOXIRI, i.e., the combination of folinic acid, 5-fluorouracil, oxaliplatin, and irinotecan, is a first-line treatment for colorectal carcinoma (CRC), yet non-personalized and aggressive. In this study, to mimic the clinical situation of patients diagnosed with advanced CRC and exposed to a chronic treatment with FOLFOXIRI, we have generated the CRC cell clones chronically treated with FOLFOXIRI. A significant...

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PMID: 36230735
DOI: 10.3390/cancers14194812

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