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Article

Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-κB.

Oncogene - 1 Feb 2021

Periyasamy Manikandan, Singh Anup K, Gemma Carolina, Farzan Raed, Allsopp Rebecca C, Shaw Jacqueline A, Charmsaz Sara, Young Leonie S, Cunnea Paula, Coombes R Charles, Győrffy Balázs, Buluwela Lakjaya, Ali Simak

Abstract excerpt

The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cancer and promotes tumour heterogeneity and therapy resistance. Hence, understanding the mechanisms that underlie A3B over-expression is important, especially for developing therapeutic approaches to reducing A3B levels, and consequently limiting cancer mutagenesis. We previously demonstrated that A3B is repressed by p53 and p53...

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Identifiers

PMID: 33323971
DOI: 10.1038/s41388-020-01583-7
PMCID: PMC7116738

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Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-κB.PMID 33323971Read ↗

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