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Article

Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy.

Cell reports. Medicine - 17 Dec 2024

Shi Min, Yang Yingxi, Huang Na, Zeng Dongqiang, Mo Zongchao, Wang Jiao, Zhang Xiaomeng, Liu Ran, Wang Chunlin, Rong Xiaoxiang, Wu Zhenzhen, Huang Qiong, Shang Haixia, Tang Jihong, Wang Zhaojun, Cai Jianan, Huang Genjie, Guan Yijin, Guo Jian, Mu Quanhua, Wang Jiguang, Liao Wangjun

Abstract excerpt

Drug resistance limits the efficacy of chemotherapy for colorectal cancer liver metastasis (CRLM). However, the evolution of CRLM during drug treatment remains poorly elucidated. Multi-omics and treatment response data from 115 samples of 49 patients with CRLM undergoing bevacizumab (BVZ)-based chemotherapy show little difference in genomic alterations in 92% of cases, while remarkable differences are observed at...

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Identifiers

PMID: 39631402
DOI: 10.1016/j.xcrm.2024.101838
PMCID: PMC11722126

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STAT3
SMAD4

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