Back to search

Article

Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction

2023-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Obesity increases the morbidity and mortality of traumatic brain injury (TBI). We performed a detailed analysis of transcriptomic changes in the brain and adipose tissue to examine the interactive effects between high-fat diet-induced obesity (DIO) and TBI in relation to central and peripheral inflammatory pathways, as well as neurological function. Adult male mice were fed a high-fat diet (HFD)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ca979c8a-c2e9-52a3-8d58-5143f9c3c657
DOI
10.1101/2023.07.28.550986
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunctionDOI 10.1101/2023.07.28.550986
Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunctionSemantic proximity
Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injurySemantic proximity
Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesitySemantic proximity
Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injurySemantic proximity
Investigating multidimensional associations between obesity-related traits and brain health, and identifying potential mechanisms.Semantic proximity
A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomesSemantic proximity
Ketogenic diet alters microglial morphology and changes the hippocampal lipidomic profile distinctively in stress susceptible <i>versus</i> resistant male mice upon repeated social defeatSemantic proximity
Long-Term Cognitive Deficits After Traumatic Brain Injury Associated With Microglia ActivationSemantic proximity
CD4+ T Cell Activation and Peripheral Immune Cell Influx into the Brain Following Wildfire Smoke Exposure is Modulated by a Saturated Fat DietSemantic proximity
Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammationSemantic proximity
A proteomics-based approach reveals the role of the activation of astrocytes with the A1 phenotype in medullary neuroinflammation after TBI in mice.Semantic proximity
ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoformsSemantic proximity
Select a neighboring publication to make it the new centre.