Article

Benchmarking freely available human leukocyte antigen typing algorithms across varying genes, coverages and typing resolutions

2022-07-02

Abstract excerpt

The human leukocyte antigen (HLA) system is a group of genes coding for proteins that are central to the adaptive immune system and identifying the specific HLA allele combination of a patient is relevant in organ donation, risk assessment of autoimmune and infectious diseases and cancer immunotherapy. However, due to the high genetic polymorphism in this region, HLA typing requires specialized methods. We investi...

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Literature Corpus work: 84736151-3dc3-5b02-83a1-12060cc94148
DOI: 10.1101/2022.06.28.497888

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