Article

IGHMBP2 deletion suppresses translation and activates the integrated stress response

2023-12-12

Abstract excerpt

<h4>ABSTRACT</h4> IGHMBP2 is a non-essential, superfamily 1 DNA/RNA helicase that is mutated in patients with rare neuromuscular diseases SMARD1 and CMT2S. IGHMBP2 is implicated in translational and transcriptional regulation via biochemical association with ribosomal proteins, pre-rRNA processing factors, and tRNA-related species. To uncover the cellular consequences of perturbing IGHMBP2, we generated full and...

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Literature Corpus work: a443ad25-dcc6-58b8-bbb8-ebd6f91c58a9
DOI: 10.1101/2023.12.11.571166

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