Article

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

2022-06-18

Abstract excerpt

A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and castration-resistant models of PCa both in vitro and in vivo, and is active in PCa patient samples. Using RNA-seq transcriptome analysis and a CRISPR-based phenotyp...

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Literature Corpus work: 46062b95-6a3c-5dc0-9156-f327d74d2d4f
DOI: 10.1101/2022.06.17.496598

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