Article

Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway

2021-01-21

Abstract excerpt

The nucleolar surveillance pathway (NSP) monitors nucleolar fidelity and responds to nucleolar stresses (i.e., inactivation of ribosome biogenesis) by mediating the inhibitory binding of ribosomal proteins (RPs) to mouse double minute 2 homolog (MDM2), a nuclear-localised E3 ubiquitin ligase, which results in p53 accumulation. Inappropriate activation of the NSP has been implicated in the pathogenesis of collectio...

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Literature Corpus work: 4372b4c0-3182-5b9f-9e9c-2ed6e59ed8c8
DOI: 10.1101/2021.01.21.427535

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