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Article

Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation.

Nature communications - 15 Mar 2021

Derisbourg Maxime J, Wester Laura E, Baddi Ruth, Denzel Martin S

Abstract excerpt

Protein homeostasis is modulated by stress response pathways and its deficiency is a hallmark of aging. The integrated stress response (ISR) is a conserved stress-signaling pathway that tunes mRNA translation via phosphorylation of the translation initiation factor eIF2. ISR activation and translation initiation are finely balanced by eIF2 kinases and by the eIF2 guanine nucleotide exchange factor eIF2B. However,...

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Identifiers

PMID: 33723245
DOI: 10.1038/s41467-021-21743-x
PMCID: PMC7960713

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