Article

Investigating dual Ca <sup>2+</sup> modulation of the ryanodine receptor 1 by molecular dynamics simulation

2019-08-16

Abstract excerpt

The ryanodine receptors (RyR) are essential to calcium signaling in striated muscles. A deep understanding of the complex Ca 2+ -activation/inhibition mechanism of RyRs requires detailed structural and dynamic information for RyRs in different functional states (e.g., with Ca 2+ bound to activating or inhibitory sites). Recently, high-resolution structures of the RyR isoform 1 (RyR1) were solved by cryo-electron...

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Literature Corpus work: 0bb73ddf-f39e-5737-aadc-724629ea3cdb
DOI: 10.1101/736934

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