Article

Deciphering the mechanism of inhibition of SERCA1a by sarcolipin using molecular simulations

2019-12-17

Abstract excerpt

SERCA1a is an ATPase calcium pump that transports Ca 2+ from the cytoplasm to the sarco/endoplasmic reticulum lumen. Sarcolipin (SLN), a transmembrane peptide, regulates the activity of SERCA1a by decreasing its Ca 2+ transport rate, but its mechanism of action is still not well understood. To decipher this mechanism, we have performed normal modes analysis in the all-atom model, with the SERCA1a-SLN complex or...

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Literature Corpus work: d020af86-a667-5e2d-869d-0b1abe7663f5
DOI: 10.1101/2019.12.17.879825

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