Structural and functional interactions between the EF hand domain and S2-S3 loop in the type-1 ryanodine receptor ion channel.

doi:10.1016/j.jbc.2023.105606

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Article

Structural and functional interactions between the EF hand domain and S2-S3 loop in the type-1 ryanodine receptor ion channel.

The Journal of biological chemistry - 1 Feb 2024

Chirasani Venkat R, Elferdink Millar, Kral MacKenzie, Carter Jordan S, Heitmann Savannah, Meissner Gerhard, Yamaguchi Naohiro

Abstract excerpt

Previous cryo-electron micrographs suggested that the skeletal muscle Ca2+ release channel, ryanodine receptor (RyR)1, is regulated by intricate interactions between the EF hand Ca2+ binding domain and the cytosolic loop (S2-S3 loop). However, the precise molecular details of these interactions and functional consequences of the interactions remain elusive. Here, we used molecular dynamics simulations to explore...

Topics

Humans
Calcium
EF Hand Motifs
HEK293 Cells
Muscle, Skeletal
Mutation
Ryanodine
Ryanodine Receptor Calcium Release Channel

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Identifiers

PMID: 38159862
DOI: 10.1016/j.jbc.2023.105606
PMCID: PMC10832476

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