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Article

Structural and functional interactions between the EF hand domain and S2-S3 loop in the type-1 ryanodine receptor ion channel.

The Journal of biological chemistry - 1 Feb 2024

Chirasani Venkat R, Elferdink Millar, Kral MacKenzie, Carter Jordan S, Heitmann Savannah, Meissner Gerhard, Yamaguchi Naohiro

Abstract excerpt

Previous cryo-electron micrographs suggested that the skeletal muscle Ca2+ release channel, ryanodine receptor (RyR)1, is regulated by intricate interactions between the EF hand Ca2+ binding domain and the cytosolic loop (S2-S3 loop). However, the precise molecular details of these interactions and functional consequences of the interactions remain elusive. Here, we used molecular dynamics simulations to explore...

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Identifiers

PMID: 38159862
DOI: 10.1016/j.jbc.2023.105606
PMCID: PMC10832476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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