Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping Ryanodine Binding Sites in the Pore Cavity of Ryanodine Receptors.

Biophysical journal - 25 Apr 2017

Ngo Van A, Perissinotti Laura L, Miranda Williams, Chen S R Wayne, Noskov Sergei Y

Abstract excerpt

Ryanodine (Ryd) irreversibly targets ryanodine receptors (RyRs), a family of intracellular calcium release channels essential for many cellular processes ranging from muscle contraction to learning and memory. Little is known of the atomistic details about how Ryd binds to RyRs. In this study, we used all-atom molecular dynamics simulations with both enhanced and bidirectional sampling to gain direct insights...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Molecular Docking Simulation
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Structure, Secondary

Share to Ryanodine Receptor Calcium Release Channel

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 28445755
DOI: 10.1016/j.bpj.2017.03.014
PMCID: PMC5406381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping Ryanodine Binding Sites in the Pore Cavity of Ryanodine Receptors.PMID 28445755Read ↗

Investigating dual Ca2+ modulation of the ryanodine receptor 1 by molecular dynamics simulation.Semantic proximity Read ↗

Toward decrypting the allosteric mechanism of the ryanodine receptor based on coarse-grained structural and dynamic modeling.Semantic proximity Read ↗

Investigating the inter-subunit/subdomain interactions and motions relevant to disease mutations in the N-terminal domain of ryanodine receptors by molecular dynamics simulation.Semantic proximity Read ↗

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule.Semantic proximity Read ↗

Investigating dual Ca <sup>2+</sup> modulation of the ryanodine receptor 1 by molecular dynamics simulationSemantic proximity Read ↗

Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism.Semantic proximity Read ↗

Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics.Semantic proximity Read ↗

Ryanodine receptors: structure and function.Semantic proximity Read ↗

Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.Semantic proximity Read ↗

Ryanodine Receptor Structure and Function in Health and Disease.Semantic proximity Read ↗

Computational Analysis of Binding Interactions between the Ryanodine Receptor Type 2 and Calmodulin.Semantic proximity Read ↗

Molecular Dynamics Simulations of the Cardiac Ryanodine Receptor Type 2 (RyR2) Gating Mechanism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.