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Article

Molecular Dynamics Simulations of the Cardiac Ryanodine Receptor Type 2 (RyR2) Gating Mechanism.

The journal of physical chemistry. B - 1 Dec 2022

Greene D'Artagnan, Barton Michael, Luchko Tyler, Shiferaw Yohannes

Abstract excerpt

Mutations in the cardiac ryanodine receptor type 2 (RyR2) have been linked to fatal cardiac arrhythmias such as catecholaminergic polymorphic ventricular tachycardia (CPVT). While many CPVT mutations are associated with an increase in Ca2+ leak from the sarcoplasmic reticulum, the mechanistic details of RyR2 channel gating are not well understood, and this poses a barrier in the development of new pharmacological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36384028
DOI: 10.1021/acs.jpcb.2c03031
PMCID: PMC9720719

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