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Article

Investigating dual Ca2+ modulation of the ryanodine receptor 1 by molecular dynamics simulation.

Proteins - 1 Nov 2020

Zheng Wenjun, Wen Han

Abstract excerpt

The ryanodine receptors (RyR) are essential to calcium signaling in striated muscles. A deep understanding of the complex Ca2+ -activation/inhibition mechanism of RyRs requires detailed structural and dynamic information for RyRs in different functional states (eg, with Ca2+ bound to activating or inhibitory sites). Recently, high-resolution structures of the RyR isoform 1 (RyR1) were solved by cryo-electron...

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Identifiers

PMID: 32557910
DOI: 10.1002/prot.25971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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