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Article

Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics.

The Journal of general physiology - 6 Jan 2020

Yamazawa Toshiko, Ogawa Haruo, Murayama Takashi, Yamaguchi Maki, Oyamada Hideto, Suzuki Junji, Kurebayashi Nagomi, Kanemaru Kazunori, Oguchi Katsuji, Sakurai Takashi, Iino Masamitsu

Abstract excerpt

Type 1 ryanodine receptor (RYR1) is a Ca2+ release channel in the sarcoplasmic reticulum in skeletal muscle and plays an important role in excitation-contraction coupling. Mutations in the RYR1 gene cause severe muscle diseases such as malignant hyperthermia (MH), which is a disorder of CICR via RYR1. Thus far, >300 mutations in RYR1 have been reported in patients with MH. However, owing to a lack of...

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Identifiers

PMID: 31841587
DOI: 10.1085/jgp.201812235
PMCID: PMC7034096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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