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Article

Potential Rad54 separation of function mutation highlights unique roles during homologous recombination.

PLoS genetics - 1 Apr 2026

Hu Jingyi, Moraga David, Xu Amanda, Peysakhova Lauren, Crickard J Brooks

Abstract excerpt

Homologous recombination (HR) is a DNA repair pathway that utilizes a template-based approach to repair double-strand breaks within the genome. Template use requires the exchange of individual DNA strands, which members of the RecA family of recombinases facilitate. Rad51 is a primary strand exchange factor in eukaryotes. During regular mitotic DNA repair, Rad51 is aided by the DNA translocase Rad54, which acts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42044161
DOI: 10.1371/journal.pgen.1012136
PMCID: PMC13138755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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