Article

Fetal hemoglobin enables malaria parasite growth in sickle cells but augments production of transmission stage parasites

2024-09-06

Abstract excerpt

Sickle cell trait is the quintessential example of the human response to malaria, providing protection against severe disease, but leading to sickle cell disease (SCD) in the homozygous state. Fetal Hemoglobin (HbF) reduces the pathology of SCD and several mutations lead to the prolonged production of HbF into childhood and adult life. HbF has been suggested to contribute to protection against malaria. Two long-te...

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Literature Corpus work: 0b585a16-cdf3-5e6f-8477-c029ee2bdda6
DOI: 10.1101/2024.09.05.24313101

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