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<em>Plasmodium falciparum</em> (<em>Pf</em>), Coevolutionary Balance, and Therapeutically-Rational Exchange Transfusion (T-REX): Nearly All <em>Pf</em> Genomes Allow HbAS Hemoglobin to Promote Human Survival

2026-02-12

Abstract excerpt

<h4>Background: </h4> While Plasmodium falciparum (Pf) genomes are constantly evolving to counter new antimalarial drugs, Pf parasites currently allow ancient Pf-malaria-combating red blood cell (RBC) genetic variants to markedly protect humans against onset of severe Pf disease and death. The prevalences of sickle-trait hemoglobin (HbAS) RBCs and “dual-gene protection” type-O HbAS RBCs are substantial in Pf-endem...

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Literature Corpus work
06904622-7269-5cc8-8897-4638b6994a98
DOI
10.20944/preprints202602.0842.v1
Open publication

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<em>Plasmodium falciparum</em> (<em>Pf</em>), Coevolutionary Balance, and Therapeutically-Rational Exchange Transfusion (T-REX): Nearly All <em>Pf</em> Genomes Allow HbAS Hemoglobin to Promote Human SurvivalDOI 10.20944/preprints202602.0842.v1
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