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Article

Fetal hemoglobin in sickle cell anemia: a glass half full?

Blood - 23 Jan 2014

Steinberg Martin H, Chui David H K, Dover George J, Sebastiani Paola, Alsultan Abdulrahman

Abstract excerpt

Fetal hemoglobin (HbF) modulates the phenotype of sickle cell anemia by inhibiting deoxy sickle hemoglobin (HbS) polymerization. The blood concentration of HbF, or the number of cells with detectable HbF (F-cells), does not measure the amount of HbF/F-cell. Even patients with high HbF can have severe disease because HbF is unevenly distributed among F-cells, and some cells might have insufficient concentrations...

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Identifiers

PMID: 24222332
DOI: 10.1182/blood-2013-09-528067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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