Article

HbF/F-cell and the Phenotype of Sickle Cell Disease

2026-06-04

Abstract excerpt

Fetal hemoglobin (HbF) prevents the polymerization of sickle hemoglobin (HbS). HbF, measured usually as a percent of total hemoglobin (%HbF), is inversely associated with the severity of sickle cell disease (SCD) but fails to capture the distribution of HbF concentrations within red blood cells (RBCs). The relative proportion of HbF and HbS within a RBC is reflected by the HbF:HbS ratio whereas HbF/F-cell quantifi...

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Literature Corpus work: 5dec54f5-7934-50cb-9aef-30ca9f89da62
DOI: 10.64898/2026.06.02.26354737

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