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Influence of the sickle cell trait on Plasmodium falciparum infectivity from naturally infected gametocyte carriers

10 May 2023

Abstract excerpt

BACKGROUND: Sickle cell trait (SCT) refers to the carriage of one abnormal copy of the β-globin gene, the HbS allele. SCT offers protection against malaria, controlling parasite density and preventing progression to symptomatic malaria. However, it remains unclear whether SCT also affects transmission stages and mosquito infection parameters. Deciphering the impact of the SCT on human to mosquito malaria...

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PMID: 37165325
DOI: 10.1186/s12879-023-08134-x

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