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Fetal Hemoglobin in Sickle Hemoglobinopathies: High HbF Genotypes and Phenotypes

23 Nov 2020

Abstract excerpt

Fetal hemoglobin (HbF) usually consists of 4 to 10% of total hemoglobin in adults of African descent with sickle cell anemia. Rarely, their HbF levels reach more than 30%. High HbF levels are sometimes a result of β-globin gene deletions or point mutations in the promoters of the HbF genes. Collectively, the phenotype caused by these mutations is called hereditary persistence of fetal hemoglobin, or HPFH. The...

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PMID: 33238542
DOI: 10.3390/jcm9113782

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