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Fetal hemoglobin in sickle cell anemia

14 Apr 2011

Abstract excerpt

Fetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin polymer. Fetal hemoglobin genes are genetically regulated, and the level of HbF and its distribution among sickle erythrocytes is highly variable. Some patients with sickle cell disease have exceptionally high levels of HbF that are...

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PMID: 21490337
DOI: 10.1182/blood-2011-03-325258

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