Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.

Abstract excerpt

Because autism spectrum disorders are neurodevelopmental disorders and patients typically display symptoms before the age of three, one of the key questions in autism research is whether the pathology is reversible in adults. Here we investigate the developmental requirement of Shank3 in mice, a prominent monogenic autism gene that is estimated to contribute to approximately 1% of all autism spectrum disorder...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Anxiety
• Share to Dendritic Spines
• Share to Gene Knock-In Techniques