Assessing the Impact of Colchicine on Coronary Plaque Phenotype After Myocardial Infarction with Optical Coherence Tomography: Rationale and Design of the COCOMO-ACS Study.

doi:10.1007/s10557-021-07240-9

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Assessing the Impact of Colchicine on Coronary Plaque Phenotype After Myocardial Infarction with Optical Coherence Tomography: Rationale and Design of the COCOMO-ACS Study.

Cardiovascular drugs and therapy - 1 Dec 2022

Montarello Nicholas J, Singh Kuljit, Sinhal Ajay, Wong Dennis T L, Alcock Richard, Rajendran Sharmalar, Dautov Rustem, Barlis Peter, Patel Sanjay, Nidorf Stefan M, Thompson Peter L, Salagaras Thalia, Butters Julie, Nerlekar Nitesh, Di Giovanni Giuseppe, Ottaway Juanita L, Nicholls Stephen J, Psaltis Peter J

Abstract excerpt

INTRODUCTION: Recurrent event rates after myocardial infarction (MI) remain unacceptably high, in part because of the continued growth and destabilization of residual coronary atherosclerotic plaques, which may occur despite lipid-lowering therapy. Inflammation is an important contributor to this ongoing risk. Recent studies have shown that the broad-acting anti-inflammatory agent, colchicine, may reduce adverse...

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Identifiers

PMID: 34432196
DOI: 10.1007/s10557-021-07240-9
PMCID: PMC8384919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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