Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression.

The Journal of clinical investigation - 1 Aug 2017

Rahman Karishma, Vengrenyuk Yuliya, Ramsey Stephen A, Vila Noemi Rotllan, Girgis Natasha M, Liu Jianhua, Gusarova Viktoria, Gromada Jesper, Weinstock Ada, Moore Kathryn J, Loke P'ng, Fisher Edward A

Abstract excerpt

Atherosclerosis is a chronic inflammatory disease, and developing therapies to promote its regression is an important clinical goal. We previously established that atherosclerosis regression is characterized by an overall decrease in plaque macrophages and enrichment in markers of alternatively activated M2 macrophages. We have now investigated the origin and functional requirement for M2 macrophages in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to CX3C Chemokine Receptor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperlipidemias

Share to Plaque, Atherosclerotic

Share to Receptors, CCR2

Share to Receptors, CCR5

Share to Receptors, Chemokine

Share to STAT6 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 28650342
DOI: 10.1172/JCI75005
PMCID: PMC5531402

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression.PMID 28650342Read ↗

Macrophages in Atherosclerosis Regression.Semantic proximity Read ↗

Regression of Atherosclerosis Is Characterized by Broad Changes in the Plaque Macrophage TranscriptomeSemantic proximity Read ↗

Macrophage Trafficking, Inflammatory Resolution, and Genomics in AtherosclerosisSemantic proximity Read ↗

CD47 Blockade Reprograms the Monocyte-Macrophage Axis to Promote Inflammation Resolution in AtherosclerosisSemantic proximity Read ↗

Macrophage Plasticity and Atherosclerosis TherapySemantic proximity Read ↗

Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and RegressionSemantic proximity Read ↗

GATA2 Expression by Intima-Infiltrating Macrophages Drives Early Atheroma FormationSemantic proximity Read ↗

The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophagesSemantic proximity Read ↗

STAT6 Upregulation Promotes M2 Macrophage Polarization to Suppress Atherosclerosis.Semantic proximity Read ↗

Understanding the role of alternative macrophage phenotypes in human atherosclerosis.Semantic proximity Read ↗

Clinical significance of macrophage phenotypes in cardiovascular diseaseSemantic proximity Read ↗

Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.