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Article

The effect of colchicine on cholesterol crystal formation, expansion and morphology: a potential mechanism in atherosclerosis

16 Feb 2024

Abstract excerpt

Background Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Thus, agents that affect CC formation, expansion, and morphology may reduce cardiovascular (CV) risk independent of lipid-lowering and anti-inflammatory therapy. Objective...

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PMID: 38495937
DOI: 10.3389/fcvm.2024.1345521

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