Article

Genetically informed search for potential osteoarthritis drug targets across the proteome

2026-02-11

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Osteoarthritis (OA) is a leading cause of disability worldwide, yet no licensed therapies can prevent or slow its progression. We aimed to identify potential targets for disease-modifying OA drugs (DMOADs) by integrating genetic and differential protein expression (DPE) evidence. <h4>Methods</h4> We evaluated genetically predicted perturbations of plasma protein levels using...

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Literature Corpus work: 0acba3f4-a8ec-5ad0-9891-2340ec3a8fb0
DOI: 10.64898/2026.02.10.26345885

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