Article
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.
Nature genetics - 1 Apr 2018
Zengini Eleni, Hatzikotoulas Konstantinos, Tachmazidou Ioanna, Steinberg Julia, Hartwig Fernando P, Southam Lorraine, Hackinger Sophie, Boer Cindy G, Styrkarsdottir Unnur, Gilly Arthur, Suveges Daniel, Killian Britt, Ingvarsson Thorvaldur, Jonsson Helgi, Babis George C, McCaskie Andrew, Uitterlinden Andre G, van Meurs Joyce B J, Thorsteinsdottir Unnur, Stefansson Kari, Davey Smith George, Wilkinson Jeremy M, Zeggini Eleftheria
Abstract excerpt
Osteoarthritis is a common complex disease imposing a large public-health burden. Here, we performed a genome-wide association study for osteoarthritis, using data across 16.5 million variants from the UK Biobank resource. After performing replication and meta-analysis in up to 30,727 cases and 297,191 controls, we identified nine new osteoarthritis loci, in all of which the most likely causal variant was...
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