Decoding the genomic basis of osteoarthritis

Abstract excerpt

Osteoarthritis causes pain and functional disability for a quarter of a billion people worldwide, with no disease-stratifying tools nor modifying therapy. Here, we use primary cartilage and synovium from osteoarthritis patients to construct a molecular quantitative trait locus map of gene expression and protein abundance. By integrating data across omics levels, we identify likely effector genes for osteoarthritis...

Topics

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• Gene Expression Profiling
• Gene Expression Regulation
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Osteoarthritis
• Quantitative Trait Loci
• Transcription Factors
• Transcriptome

Identifiers and source

Literature Corpus work

8ae1eead-ff54-504f-9578-b59b1a899bd2

DOI

10.1101/835850