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Article

Identification of novel drug targets for osteoarthritis by integrating genetics and proteomes from blood.

Journal of orthopaedic surgery and research - 11 Sept 2024

Song Shan, Qiao Jun, Zhao Rong, Lu Yu-Jie, Wang Can, Chang Min-Jing, Zhang He-Yi, Li Xiao-Feng, Wang Cai-Hong

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is a degenerative osteoarticular disease, involving genetic predisposition. How the risk variants confer the risk of OA through their effects on proteins remains largely unknown. Therefore, we aimed to discover new and effective drug targets for OA and its subtypes. METHODS: A proteome-wide association study (PWAS) was performed based on OA and its subtypes genome-wide association...

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Genome-Wide Association Study
Mendelian Randomization Analysis
Molecular Targeted Therapy
Osteoarthritis
Osteoarthritis, Hip

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteoarthritis, Knee

Quantitative Trait Loci

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PMID: 39261869
DOI: 10.1186/s13018-024-05034-x
PMCID: PMC11389225

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