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Unraveling the shared genetic architecture of osteoarthritis and metabolic traits through multi-omics insights.

Osteoarthritis and cartilage - 1 Mar 2026

Liao Binzhi, Mu Yumeng, Luo Mengliang, Liu Yinjiang, Yang Qingtao, Yang Haibo, Ye Jihua, Wu Yuanyuan, Cheng Feifei, Sun Xianding, Nie Mao

Abstract excerpt

OBJECTIVE: Osteoarthritis (OA) often coexists with metabolic traits (MTs), causing significant disability. Our study aims to uncover the shared genetic mechanisms between OA and MTs, revealing novel OA-MT related genes, proteins and pathways. DESIGN: We first explored the clinical associations between OA and MTs based on UK Biobank data. Using GWAS statistics for 9 OA subtypes and 51 MTs, we identified both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41167325
DOI: 10.1016/j.joca.2025.10.010

Genes

ANAPC4
SLC39A8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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