Article

Structural phenotypes of osteoarthritis are clinically and genetically distinct: findings from 59,539 UK Biobank participants

2026-02-10

Abstract excerpt

<h4>OBJECTIVES</h4> Osteoarthritis is a heterogeneous disease, with diverse structural patterns likely reflecting distinct genetic drivers. Robust, data-driven methods to identify and characterise such phenotypes are lacking. This study leveraged the UK Biobank to define machine learning–derived structural osteoarthritis phenotypes and evaluate their clinical and genetic profiles. <h4>METHODS</h4> Machine learni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40bb35f7-3c56-5947-b566-4f5b7d9cf883
DOI: 10.64898/2026.02.08.26345686

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural phenotypes of osteoarthritis are clinically and genetically distinct: findings from 59,539 UK Biobank participantsDOI 10.64898/2026.02.08.26345686Read

Osteoarthritis phenotypes: advancing precision medicine through clinical, structural, and molecular stratification.Semantic proximity Read

The genetic architecture of osteoarthritis: insights from UK BiobankSemantic proximity Read

A comprehensive descriptive analysis of hip and knee radiographic osteoarthritis in the UK Biobank in relation to joint pain, joint site interrelationships, obesity, race and deprivation: Findings from 59,475 individualsSemantic proximity Read

Genetics of osteoarthritis: Insights from GWAS to therapeutic opportunities.Semantic proximity Read

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.Semantic proximity Read

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.Semantic proximity Read

Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers.Semantic proximity Read

Deep learning based phenotyping of medical images improves power for gene discovery of complex diseaseSemantic proximity Read

The Genetic Epidemiological Landscape of Hip and Knee Osteoarthritis: Where Are We Now and Where Are We Going?Semantic proximity Read

Genetic liability to meniscus degeneration and its comorbidity patterns: a phenome-wide association study in the UK BiobankSemantic proximity Read

Recent advances in understanding the phenotypes of osteoarthritisSemantic proximity Read

A molecular quantitative trait locus map for osteoarthritis.Semantic proximity Read