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Article

Proteome-wide Mendelian randomization identifies therapeutic targets for ankylosing spondylitis

19 Mar 2024

Abstract excerpt

Background Ankylosing Spondylitis (AS) is a chronic inflammatory disorder which can lead to considerable pain and disability. Mendelian randomization (MR) has been extensively applied for repurposing licensed drugs and uncovering new therapeutic targets. Our objective is to pinpoint innovative therapeutic protein targets for AS and assess the potential adverse effects of druggable proteins. Methods We conducted a...

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Share to Genetic Associations and Epidemiology
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38566994
DOI: 10.3389/fimmu.2024.1366736

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