Article

Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter

2022-04-13

Abstract excerpt

<h4>ABSTRACT</h4> The Amino Acid-Polyamine-Organocation transporter GadC contributes to the survival of pathogenic bacteria under extreme acid stress by exchanging extracellular glutamate for intracellular GABA. Its structure, determined exclusively in an inward-facing conformation at alkaline pH, consists of the canonical LeuT-fold of a conserved five-helix inverted repeat, thereby resembling functionally diverg...

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Literature Corpus work: 0a727813-7ac1-51c4-99fa-c49a65bf6538
DOI: 10.1101/2022.04.13.488180

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