Article

A cationic lipid site at the outward transmembrane face of a pentameric ligand-gated ion channel

2021-03-25

Abstract excerpt

Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction from bacteria to humans. Lipids play an important role in regulating pLGIC function, yet the structural basis for specific pLGIC-lipid interactions remains poorly understood. The bacterial channel ELIC recapitulates several properties of eukaryotic pLGICs, including activation by the neurotransmitter GABA and...

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Identifiers and source

Literature Corpus work: 9cf16548-43b4-527a-a633-6ea432e5f747
DOI: 10.1101/2021.03.24.436810

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