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Article

Transport domain unlocking sets the uptake rate of an aspartate transporter.

Nature - 5 Feb 2015

Akyuz Nurunisa, Georgieva Elka R, Zhou Zhou, Stolzenberg Sebastian, Cuendet Michel A, Khelashvili George, Altman Roger B, Terry Daniel S, Freed Jack H, Weinstein Harel, Boudker Olga, Blanchard Scott C

Abstract excerpt

Glutamate transporters terminate neurotransmission by clearing synaptically released glutamate from the extracellular space, allowing repeated rounds of signalling and preventing glutamate-mediated excitotoxicity. Crystallographic studies of a glutamate transporter homologue from the archaeon Pyrococcus horikoshii, GltPh, showed that distinct transport domains translocate substrates into the cytoplasm by moving...

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PMID: 25652997
DOI: 10.1038/nature14158
PMCID: PMC4351760

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