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Article

APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions.

Cell reports - 10 Nov 2015

Kazanov Marat D, Roberts Steven A, Polak Paz, Stamatoyannopoulos John, Klimczak Leszek J, Gordenin Dmitry A, Sunyaev Shamil R

Abstract excerpt

An antiviral component of the human innate immune system-the APOBEC cytidine deaminases-was recently identified as a prominent source of mutations in cancers. Here, we investigated the distribution of APOBEC-induced mutations across the genomes of 119 breast and 24 lung cancer samples. While the rate of most mutations is known to be elevated in late-replicating regions that are characterized by reduced chromatin...

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Identifiers

PMID: 26527001
DOI: 10.1016/j.celrep.2015.09.077
PMCID: PMC4644490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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