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Article

Distinct molecular profiles associated with early vs late genome instability in cancer.

Scientific reports - 6 Apr 2026

Gourmet Lucie, Lam James, Pennycuick Adam, Zapata Luis, Mallick Parag, Walker-Samuel Simon

Abstract excerpt

The temporal order in which cancer hallmark phenotypes emerge can influence tumor behavior and prognosis. In prior work, we used variant allele frequency (VAF) analysis to infer hallmark acquisition order in over 30,000 tumors, identifying two dominant evolutionary trajectories: one characterized by early genome instability (EGI) and the other by late genome instability (LGI). These trajectories were associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41942602
DOI: 10.1038/s41598-026-44528-y
PMCID: PMC13216520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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