Article

Loop Extrusion Accelerates Long-Range Enhancer-Promoter Searches in Living Embryos

2026-02-18

Abstract excerpt

<h4>SUMMARY</h4> Long-range gene regulation underlies a variety of human developmental disorders including Cornelia de Lange syndrome 1 and polydactyly 2 . Cohesin-mediated loop extrusion and tether-like elements are two major mechanisms implicated in fostering long-range enhancer-promoter (E-P) contacts 3 . However, our understanding of the contributions of these mechanisms to the kinetics of E-P interactions...

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Literature Corpus work: e514fbe3-e5a7-508c-b225-7d85bf761eb2
DOI: 10.64898/2026.02.17.706355

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