Article

Multi-omics analysis identifies intrinsic <i>Trp53</i> driven metastatic breast cancer subtypes

2026-02-18

Abstract excerpt

Metastatic breast cancer (mBC) is deadly, and its molecular drivers are largely unknown. Treatment is limited to systemic cytotoxic chemotherapies and tumors often become refractory. The most frequently mutated gene in MBC is TP53 . The TP53 R248W hotspot missense mutation is associated with poor prognosis. We generated a somatic mouse model of mammary epithelial specific Trp53 R245W expression. Primary tumor...

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Identifiers and source

Literature Corpus work: 0a42a97e-0e1a-5490-91cb-68e2c2ee5fe4
DOI: 10.64898/2026.02.16.706177

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