Article
S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis.
Breast cancer research : BCR - 27 Dec 2019
Yuan Wenlin, Goldstein Leonard D, Durinck Steffen, Chen Ying-Jiun, Nguyen Thong T, Kljavin Noelyn M, Sokol Ethan S, Stawiski Eric W, Haley Benjamin, Ziai James, Modrusan Zora, Seshagiri Somasekar
Abstract excerpt
BACKGROUND: PIK3CA mutations are frequent in human breast cancer. Pik3caH1047R mutant expression in mouse mammary gland promotes tumorigenesis. TP53 mutations co-occur with PIK3CA mutations in human breast cancers. We previously generated a conditionally activatable Pik3caH1047R;MMTV-Cre mouse model and found a few malignant sarcomatoid (spindle cell) carcinomas that had acquired spontaneous dominant-negative...
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