Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases

21 Sept 2018

Abstract excerpt

TP53 mutations are the most frequent genetic alterations in breast cancer and are associated with more aggressive disease and worse overall survival. We have created two conditional mutant Trp53 alleles in the mouse that allow expression of Trp53R172H or Trp53R245W missense mutations in single cells surrounded by a normal stroma and immune system. Mice with Trp53 mutations in a few breast epithelial cells develop...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30262850
DOI: 10.1038/s41467-018-06146-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastasesPMID 30262850Read ↗

Multi-omics analysis identifies intrinsic <i>Trp53</i> driven metastatic breast cancer subtypesSemantic proximity Read ↗

Triple-negative breast tumors are dependent on mutant p53 for growth and survival.Semantic proximity Read ↗

Insights into Wild-Type and Mutant p53 Functions Provided by Genetically Engineered MiceSemantic proximity Read ↗

p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator.Semantic proximity Read ↗

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer.Semantic proximity Read ↗

Mice carrying nonsense mutant p53 develop frequent multicentric or metastatic tumorsSemantic proximity Read ↗

Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In VivoSemantic proximity Read ↗

Targeting mutant p53: a key player in breast cancer pathogenesis and beyond.Semantic proximity Read ↗

The genomic landscape of metastasis in treatment-naïve breast cancer models.Semantic proximity Read ↗

Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutantsSemantic proximity Read ↗

A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancerSemantic proximity Read ↗

Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.