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Article

Elucidating cooperative genetic events in DCIS progression in mutant p53-driven breast cancer.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2026

Morrissey Rhiannon L, McDaniel Joy M, Chau Gilda P, Su Xiaoping, V Mitheera, Chandra Vidhi, Dixon Beverly R E A, El-Naggar Adel K, Thompson Alastair M, Lozano Guillermina

Abstract excerpt

Ductal carcinoma in situ (DCIS) is a precursor mammary lesion characterized by abnormal epithelial cells in mammary ducts that remain confined to the luminal space. Not all DCIS becomes invasive, and no strategy currently exists in patients to stratify indolent DCIS from DCIS at risk of progression. Several studies of human DCIS and breast cancer suggest that TP53 mutations occur early in DCIS. However, TP53...

Read the complete abstract on PubMed

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Share to Breast Neoplasms
Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Gene Expression Regulation, Neoplastic

Share to Membrane Proteins

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Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41505521
DOI: 10.1073/pnas.2526544123
PMCID: PMC12799145

Genes

TP53
TMEM267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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