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Article

Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model

23 Jul 2020

Abstract excerpt

Background Tumor models are critical for our understanding of cancer and the development of cancer therapeutics. The 4T1 murine mammary cancer cell line is one of the most widely used breast cancer models. Here, we present an integrated map of the genome, transcriptome and immunome of 4T1. Results We found Trp53 (Tp53) and Pik3g to be mutated. Other frequently mutated genes in breast cancer, including Brca1 and...

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PMID: 32793490
DOI: 10.3389/fonc.2020.01195

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