Article
Mutant p53 regulates Survivin to foster lung metastasis.
Genes & development - 1 Apr 2021
Tang Qiaosi, Efe Gizem, Chiarella Anna M, Leung Jessica, Chen Maoting, Yamazoe Taiji, Su Zhenyi, Pitarresi Jason R, Li Jinyang, Islam Mirazul, Karakasheva Tatiana, Klein-Szanto Andres J, Pan Samuel, Hu Jianhua, Natsugoe Shoji, Gu Wei, Stanger Ben Z, Wong Kwok-K, Diehl J Alan, Bass Adam J, Nakagawa Hiroshi, Murphy Maureen E, Rustgi Anil K
Abstract excerpt
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide and evolves often to lung metastasis. P53R175H (homologous to Trp53R172H in mice) is a common hot spot mutation. How metastasis is regulated by p53R175H in ESCC remains to be investigated. To investigate p53R175H-mediated molecular mechanisms, we used a carcinogen-induced approach in Trp53R172H/- mice to model ESCC. In the...
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