Article

The Genetic Drivers and Therapeutic Vulnerabilities of Metastatic Breast Cancer

2026-03-13

Abstract excerpt

<title>Abstract</title> <p>The understanding of genetic basis and potential therapeutic targets for metastatic breast cancer (mBC) remains limited. Here we systematically identify the genetic and epigenetic causes underlying breast cancer metastasis from clinically defined alterations through multiplexed CRISPR knockout and base editing screens in various models. Multiple drivers converge on the down-regulation o...

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Literature Corpus work: 59be0fe1-3659-5e4b-ba2d-8235353e5a7a
DOI: 10.21203/rs.3.rs-8902045/v1

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