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Article

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53 deficient mammary cancers

1 Jan 2016

Abstract excerpt

Targeted therapies against basal-like breast tumors, which are typically 'triple-negative breast cancers (TNBCs)', remain an important unmet clinical need. Somatic TP53 mutations are the most common genetic event in basal-like breast tumors and TNBC. To identify additional drivers and possible drug targets of this subtype, a comparative study between human and murine tumors was performed by utilizing a murine...

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PMID: 27149990
DOI: 10.1242/dmm.025239

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